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Ephedplics E-I: three lignans and two benzofuran-type compounds from the roots of Ephedra sinica Stapf and their
Yunlong Dou1,2, Bowen Zhang1,2, Meng Li1,2
1School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, People's Republic of China.
Abstract:
Five new compounds Ephedplics E-I were isolated from the roots of Ephedra sinica Stapf, including three lignans (1-3) and two benzofuran-type compounds (4-5). Their structures were elucidated by spectroscopic methods, involving UV, IR, NMR spectra and HRESIMS analyses. The absolute configuration of compounds 1-5 was determined by comparing their experimental and calculated ECD spectra. All compounds were assessed for their neuroprotective activities against damage induced by corticosterone (CORT) in PC-12 cells. Compounds 1 and 2 were capable of significantly ameliorating CORT-induced PC-12 injury.
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