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Updated: Aug 6, 2026

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
07:36

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

Dual-recognizing antibodies targeting CEACAMs in the tumor microenvironment: towards more precise targeting

Jiayi Ye1,2,3, Yijun Zhao1,2,3, Shuyang Mao2,3,4

  • 1Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Cell Communication and Signaling : CCS
|July 17, 2026
PubMed

Insights

This review explores the Carcinoembryonic Antigen-Related Cell Adhesion Molecule (CEACAM) family

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • The tumor microenvironment (TME) significantly influences cancer progression.
  • The Carcinoembryonic Antigen-Related Cell Adhesion Molecule (CEACAM) family is aberrantly expressed in cancers, regulating the TME.
  • Current CEACAM-targeting antibody drugs face challenges due to toxicity and limited efficacy from normal tissue expression.

Purpose of the Study:

  • To systematically review CEACAM family structure and tumor-promoting mechanisms.
  • To analyze limitations of existing CEACAM-targeting antibody drugs.
  • To propose novel strategies for enhanced cancer therapy targeting the TME.

Main Methods:

  • Literature review of CEACAM family structure, function, and TME regulation.
  • Analysis of clinical trial data for CEACAM-targeting antibodies.
  • Development of a conceptual framework for optimized antibody design.

Main Results:

  • CEACAMs exhibit diverse structural features and mechanistic roles in tumor promotion.
  • Existing antibody therapies show significant toxicity and limited efficacy due to off-target effects.
  • A novel "dual-recognition" antibody framework is proposed for precision targeting.

Conclusions:

  • Understanding CEACAMs' dual role in normal and tumor tissues is crucial.
  • Optimizing antibody strategies by targeting epitopes, molecules, and the environment can improve efficacy and reduce toxicity.
  • Precision targeting approaches offer a promising direction for future cancer therapeutics.
Keywords:
Carcinoembryonic antigen-related cell adhesion molecule familyGlycopeptide-specific antibodyImmunotherapyTumor microenvironment

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