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Associations between granulysin and ovarian endometriosis: A 2-sample Mendelian randomization study
Baoyu Lai1, Meixing Yu2, Yunsheng Liao2
1Department of Obstetrics and Gynecology, Guangzhou Medical University, Guangzhou, China.
Medicine
|July 18, 2026
Summary
This study explored the link between granulysin and ovarian endometriosis (EMS). Findings suggest granulysin may reduce the risk of developing ovarian EMS, indicating a potential protective role.
Area of Science:
- Reproductive biology
- Immunology
- Genetics
Background:
- Endometriosis (EMS) is a chronic inflammatory condition where endometrial-like tissue grows outside the uterus.
- Ovarian EMS is the most common form, but its causes are not fully understood.
- The specific role of granulysin in ovarian EMS development requires investigation.
Purpose of the Study:
- To investigate the potential causal relationship between granulysin and ovarian EMS.
- To determine if granulysin influences the risk of developing ovarian EMS.
Main Methods:
- A 2-sample Mendelian randomization analysis was employed.
- Genome-wide association study data for granulysin and ovarian EMS were utilized.
- Inverse-variance weighted, weighted median, and MR-Egger regression methods were used for analysis, alongside sensitivity tests.
Main Results:
- A statistically significant inverse causal relationship was found between granulysin expression and ovarian EMS.
- Increased granulysin was associated with a reduced risk of ovarian EMS (OR = 0.892, 95% CI: 0.824-0.966).
Conclusions:
- The study suggests a direct, negative causal link between granulysin expression and ovarian EMS.
- Granulysin may play a protective role in the pathogenesis of ovarian EMS.
