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The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
Published on: January 13, 2023
Biologically-Oriented Alveolar Ridge Preservation (BARP) in Intact and Compromised Extraction Sockets
Mattia Pramstraller1,2,3, Roberto Farina1,2, Anina Nives Zuercher4
1Research Centre for the Study of Periodontal and Peri-Implant Diseases, University of Ferrara, Ferrara, Italy.
Journal of Periodontal Research
|July 18, 2026
Summary
Alveolar ridge preservation (ARP) effectively maintains bone dimensions after tooth extraction using the Biologically-oriented Alveolar Ridge Preservation (BARP) concept. This selective grafting approach promotes healing while preventing significant ridge collapse.
Area of Science:
- Dentistry
- Oral Surgery
- Regenerative Medicine
Background:
- Alveolar ridge preservation (ARP) is crucial after tooth extraction to prevent bone loss.
- Buccal bone dehiscence presents significant challenges for traditional ARP methods.
- Post-extraction remodeling primarily impacts the coronal portion of the alveolar ridge.
Purpose of the Study:
- To evaluate the efficacy of the Biologically-oriented Alveolar Ridge Preservation (BARP) concept and its modified application (mBARP) for compromised sockets.
- To assess the ability of BARP/mBARP to preserve ridge dimensions and promote new bone formation.
- To investigate the clinical, radiographic, and histological outcomes of selective compartmentalized grafting.
Main Methods:
- Implementation of the BARP/mBARP protocols involving selective compartmentalized grafting in 30 extraction sites.
- Utilizing a collagen sponge in the apical socket for spontaneous healing and xenograft particles with a collagen sponge in the coronal portion for reinforcement.
- In compromised sockets, an additional collagen sponge was used for enhanced graft containment and soft tissue support.
Main Results:
- Effective preservation of ridge dimensions with minimal vertical loss (+0.3 mm) and limited horizontal reduction (0.7-1.0 mm) after 4-6 months.
- Controlled buccal soft tissue contraction (2.0-2.2 mm) and substantial new bone formation (38%-40%).
- Residual graft particles remained primarily confined to the coronal compartment, indicating successful compartmentalization.
Conclusions:
- The BARP concept and its modified application (mBARP) demonstrate favorable clinical, radiographic, and histological outcomes.
- Selective coronal grafting is an effective strategy for preserving alveolar ridge dimensions.
- This approach successfully maintains physiological healing in the deeper socket portion while reinforcing the coronal area.