Related Experiment Video
Updated: Aug 6, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
When "Sarcopenic Dysphagia" Is Not the Answer
Hideaki Takahata1, Atsuto Onishi2, Kei Sato2
1Department of Rehabilitation Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. takahata@nagasaki-u.ac.jp.
Abstract:
An older woman in her late 70s was referred for swallowing assessment because of recurrent aspiration pneumonia, weight loss, low body mass index, reduced handgrip strength, and slow gait speed, initially suggesting sarcopenic dysphagia. However, flexible endoscopic evaluation of swallowing and videofluoroscopic swallowing study demonstrated marked delay in swallow initiation, impaired airway protective reflexes, and reduced pharyngeal sensation despite the absence of substantial pharyngeal residue and relatively preserved upper esophageal sphincter opening. Careful reassessment of the videofluoroscopic study revealed abnormal craniovertebral alignment. Subsequent computed tomography demonstrated atlantoaxial dislocation with superior migration of the odontoid process, and magnetic resonance imaging confirmed compression of the medulla oblongata. This case highlights the importance of avoiding oversimplified attribution of dysphagia to sarcopenia and of reconsidering alternative neural or structural mechanisms when observed swallowing physiology is discordant with the presumed diagnosis.
Related Concept Videos
Esophageal Achalasia
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Pyloric Obstruction