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Romosozumab in postmenopausal women with classical Osteogenesis imperfecta
Mikolaj Bartosik1, Oskar Windels1, Felix N von Brackel1
1Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestrasse 59, 22529, Hamburg, Germany.
Archives of Osteoporosis
|July 18, 2026
Summary
Romosozumab treatment improved spinal bone density in women with Osteogenesis imperfecta (OI). While bone quality showed some improvement, effects were less pronounced than in severe osteoporosis patients.
Area of Science:
- Bone Biology and Pharmacology
- Rheumatology and Endocrinology
Background:
- Osteogenesis imperfecta (OI) is a rare genetic disorder causing brittle bones and limited treatment options.
- Sclerostin inhibition with monoclonal antibodies like Romosozumab is being investigated to enhance bone mass and reduce fragility in OI.
Purpose of the Study:
- To evaluate the efficacy of Romosozumab in improving bone quality in postmenopausal women with Osteogenesis imperfecta.
- To compare the treatment effects of Romosozumab in OI patients versus those with severe osteoporosis.
Main Methods:
- Retrospective analysis of 5 postmenopausal women with OI and 10 with severe osteoporosis (OPO) treated with Romosozumab (210 mg s.c. monthly) for 12 months.
- Assessment of bone mineral density (aBMD), bone structure (HR-pQCT), and bone turnover markers at baseline, 6, and 12 months.
Main Results:
- Romosozumab treatment led to significant increases in spinal aBMD and osteocalcin levels in OI patients, indicating an anabolic response.
- While trends suggested potential microstructural improvements in OI patients, these were not statistically significant.
- Patients with OPO exhibited more substantial gains in aBMD, improved bone microstructure, and greater bone turnover marker response compared to OI patients.
Conclusions:
- Romosozumab significantly increased spinal bone mineral density in postmenopausal women with Osteogenesis imperfecta.
- The drug's impact on hip bone density and peripheral bone microstructure was limited in OI patients compared to those with severe osteoporosis.
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