Related Experiment Video
Updated: Aug 6, 2026
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Extraintestinal Manifestations Have a Negative Impact on Quality of Life of Patients Living with Inflammatory Bowel
Jesus K Yamamoto-Furusho1, Fausto Damian Gutierrez-Herrera2
1Department of Gastroenterology, Inflammatory Bowel Disease Clinic, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico, kazuofurusho@hotmail.com.
Introduction:
Inflammatory bowel diseases (IBDs) can produce extraintestinal manifestations (EIMs) in up to 50% of patients with IBD and may have worse quality of life than the general population. In general, IBD patients with activity have worse quality of life than those who are in remission. No previous studies have explored whether EIMs can affect the quality of life in patients with IBD. The aim of this study is to evaluate whether the presence of EIM causes a worse quality of life in patients with IBD.
Methods:
A case-control study that included 243 patients diagnosed with IBD (132 without EIM and 111 with EIM). The IBDQ-32 questionnaire was administered to all patients in order to measure the quality of life. The cutoff value to consider altered quality of life was <170 points. Statistical analysis was performed using SPSS version 25.
Results:
Patients with IBD with EIMs had significantly worse quality of life than those without EIMs (p = 0.001; OR = 2.29, 95% CI: 1.3-3.8). In the subgroup analysis by dimensions of the IBDQ-32, we found that all of them, such as social function (p < 0.0001), systemic symptoms (p < 0.0001), intestinal symptoms (p < 0.0001), and emotional (p < 0.0001), were affected in all patients with EIMs.
Conclusions:
Patients with IBD and EIMs had worse quality of life compared to those without EIMs regardless of IBD activity.
More Related Videos
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
07:05Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
Related Concept Videos
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:26Inflammatory Bowel Disease I: Introduction
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...