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Updated: Aug 6, 2026

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Synthesis and Characterization of Supramolecular Colloids
Published on: April 22, 2016
Morphogenic colloids
Florent Fessler1,2, Adam W Hauser3,4, Hailiang Liu3
1Department of Chemistry, New York University, New York, NY, USA. florentfessler@nyu.edu.
Nature Communications
|July 18, 2026
Summary
Researchers created a simple platform using emulsion droplets and copolymers to mimic biological morphogenesis. This system shows reversible shape changes and internal structure formation, offering insights into life-like adaptability in synthetic systems.
Area of Science:
- Biophysics
- Materials Science
- Soft Matter Physics
Background:
- Biological morphogenesis involves complex physicochemical processes to create functional structures.
- Synthetic replication of these dynamic transformations remains a significant scientific challenge.
Purpose of the Study:
- To develop a minimal synthetic platform that recapitulates key features of biological morphogenesis.
- To investigate reversible shape morphing and topology transitions in emulsion droplets.
Main Methods:
- Utilized emulsion droplets exposed to amphiphilic triblock copolymers (BCPs).
- Observed interfacial self-assembly of BCPs and droplet swelling.
- Investigated morphological transitions tuned by BCP concentration and temperature.
Main Results:
- Droplets exhibited spontaneous topological remodeling and internalization of surrounding aqueous phase and colloids.
- A spectrum of non-spherical morphologies were stabilized and reversibly tuned.
- Transitions were synchronized across droplet populations and could be fixed via photopolymerization.
Conclusions:
- The BCP-emulsion system serves as a tractable model for studying morphogenesis principles.
- This platform advances colloidal systems toward biologically relevant complexity and life-like adaptability.
- Demonstrated a simple method for creating dynamic, adaptable synthetic structures.
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