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Updated: Aug 6, 2026

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
Single-cell technologies in mRNA cancer vaccines
Ekaterina V Ovcharenko1, Marina R Patysheva2, Kirill M Kirilenko1
1Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
None:
The fast evolution of mRNA-based cancer therapeutics requires advanced frameworks to overcome the challenges of tumor heterogeneity and the immunosuppressive tumor immune microenvironment. In this context, single-cell technologies enable characterization of immune cell subsets, intercellular communication, and therapy resistance drivers. The shift to single-cell profiling provides a transition toward the development of precision mRNA treatments tailored to the unique dynamics of an individual tumor.
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