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Microfluidics in Assessing Platelet Function
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Association between platelet-to-hemoglobin ratio and contrast-induced acute kidney injury after percutaneous coronary

Qiqiang Li1, Leigang Tian1, Lijian Li1

  • 1Department of Cardiology, Maoming People's Hospital, Maoming, Guangdong, 525099, China.

BMC Nephrology
|July 18, 2026
PubMed

Insights

A high platelet-hemoglobin ratio (PHR) is linked to increased contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI). This finding highlights PHR as an independent predictor of CI-AKI in these patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • The platelet-hemoglobin ratio (PHR) is a prognostic biomarker in coronary artery disease (CAD).
  • The association between PHR and contrast-induced acute kidney injury (CI-AKI) post-percutaneous coronary intervention (PCI) remains unclear.

Purpose of the Study:

  • To investigate the relationship between PHR and the incidence of CI-AKI in patients undergoing PCI.

Main Methods:

  • A retrospective study included 26,479 patients who underwent PCI.
  • CI-AKI was defined as a >50% increase in serum creatinine within 48 hours post-contrast.
  • Univariate and multivariable logistic regression analyses were used to assess the PHR-CI-AKI association.

Main Results:

  • CI-AKI occurred in 6.4% of patients (1,707 cases).
  • Elevated PHR was significantly associated with increased CI-AKI incidence (OR for Q4 vs. Q1: 1.42; 95% CI: 1.20-1.68; P < 0.001).
  • Restricted cubic spline analysis suggested a linear relationship between PHR and CI-AKI.

Conclusions:

  • A high PHR is strongly correlated with a higher incidence of CI-AKI.
  • PHR is identified as an independent factor associated with CI-AKI development after PCI.
Abstract

Keywords:
Contrast-induced acute kidney injuryPercutaneous coronary interventionPlatelet–hemoglobin ratio

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