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Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection
Published on: September 14, 2019
The history of cryptosporidiosis
1Bob Champion Research and Education Building, Norwich Medical School, University of East Anglia, Norwich Research Park, Rosalind Franklin Road, Norwich, NR4 7UQ, UK. d.steverding@uea.ac.uk.
Abstract:
In this review, the history of cryptosporidiosis caused by parasites of the genus Cryptosporidium is outlined. These apicomplexan parasites evolved together with their vertebrate host during the early Cambrian period. The main etiological agents of human and bovine cryptosporidiosis are the zoonotic species C. parvum and the anthroponotic species C. hominis. Palaeoparasitological data indicate that humans have been parasitised by cryptosporidia since ancient times. Although the first Cryptosporidium species was described in 1907, the protozoan was only recognised as a gastrointestinal parasite of humans and cattle in the 1980s. The parasite became known to the general public primarily through media reports of waterborne outbreaks of gastroenteritis. Cryptosporidiosis is now acknowledged as a leading cause of diarrhoeal disease worldwide, with severe health implications for young, malnourished children and immunocompromised patients, and with severe economic consequences for cattle farmers.
Insights
This review traces the history of cryptosporidiosis, a diarrheal disease caused by Cryptosporidium parasites. It highlights the parasite
Area of Science:
- Parasitology
- Evolutionary Biology
- Public Health
Background:
- Cryptosporidium parasites, apicomplexans, co-evolved with vertebrates since the Cambrian period.
- Human and bovine cryptosporidiosis are primarily caused by C. parvum and C. hominis.
- Palaeoparasitological evidence shows ancient human infections.
Purpose of the Study:
- To provide a historical overview of cryptosporidiosis.
- To detail the evolution and recognition of Cryptosporidium as a pathogen.
- To emphasize its current impact on public health and agriculture.
Main Methods:
- Historical review of scientific literature.
- Analysis of palaeoparasitological data.
- Examination of historical public health records and media reports.
Main Results:
- The first Cryptosporidium species was identified in 1907.
- Recognition as a significant human and bovine gastrointestinal pathogen occurred in the 1980s.
- Waterborne outbreaks increased public awareness.
Conclusions:
- Cryptosporidiosis is a major global cause of diarrheal disease.
- It poses severe risks to vulnerable populations (children, immunocompromised individuals).
- The disease has significant economic impacts on cattle farming.
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