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Nanofat for Injection Laryngoplasty: Office and Operative Results
Peak Woo1, Anahita Nourmahnad1
1Icahn School of Medicine at Mount Sinai New York New York USA.
Laryngoscope Investigative Otolaryngology
|July 19, 2026
Summary
Nanofat injection laryngoplasty offers a promising treatment for glottal insufficiency, improving voice quality and vocal fold closure. While early absorption can occur, it provides a viable alternative to microfat injections for long-term voice improvement.
Area of Science:
- Regenerative Medicine
- Otolaryngology
- Aesthetic Surgery
Background:
- Nanofat, an emulsified form of fat, enhances adipose-derived stem cell release.
- Glottal insufficiency can result from atrophy, paresis, or scarring, impacting voice quality.
Purpose of the Study:
- To evaluate the efficacy of nanofat injection laryngoplasty alone for lasting vocal fold bulking.
- To assess sustained long-term voice improvement following nanofat laryngoplasty.
Main Methods:
- Retrospective review of 31 patients with glottal insufficiency undergoing nanofat injection laryngoplasty (operative or office-based).
- Average injected fat volume was 0.5 mL per side, with a median follow-up of 12 months.
- Vocal fold closure and vibration assessed via stroboscopy; Voice Handicap Index-10 (VHI-10) and Cepstral Spectral Index of Dysphonia scores compared pre- and post-treatment.
Main Results:
- Significant improvement in VHI-10 scores post-treatment (p < 0.05).
- Enhanced glottic closure correlated with improved voice quality.
- Early fat absorption occurred in 29% of patients within the first year; however, most maintained good long-term function with minimal adverse effects like stiffness.
Conclusions:
- Nanofat-only lipoinjection is a potential alternative to microfat for treating glottal insufficiency.
- Office-based nanofat injection offers a practical, minimally invasive option.
- Addressing early absorption through targeted overinjection and improved fat processing is crucial for optimizing outcomes.
