Related Experiment Video
Updated: Aug 5, 2026
Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
Published on: March 14, 2019
Long-Term Bone Healing Using Autogenous Tooth Bone Graft Combined with rhBMP-2 after Enucleation of a Large
Seungtae Kim1, Jeong-Kui Ku2, Yongjun Cho1
1Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Korea.
Background:
Autogenous tooth bone graft (AutoBT), derived from extracted teeth, has emerged as a promising alternative for bone regeneration due to its osteoinductive and osteoconductive properties. Its structural and compositional similarity to bone supports physiologic bone regeneration, and it has been successfully applied in various clinical procedures. However, despite its increasing clinical application, evidence regarding the long-term outcomes of AutoBT in large cystic defects remains limited.
Case Presentation:
A 22-year-old woman presented with a 4-cm multilobular radiolucent lesion in the left mandible that was diagnosed as an odontogenic keratocyst (OKC). Following a period of decompression, cyst enucleation and bone grafting were performed using AutoBT combined with recombinant human bone morphogenetic protein-2 (rhBMP-2). Radiographic follow-up at 1.5 months, 1 year, and 3 years postoperatively demonstrated stable bone remodeling, reestablishment of the cortico-cancellous architecture, and no evidence of recurrence. The postoperative clinical course was uneventful.
Conclusion:
This case demonstrates successful long-term bone regeneration using AutoBT combined with rhBMP-2 in a large mandibular OKC defect. Although limited to a single case, these findings support the potential of AutoBT combined with rhBMP-2 as a reliable graft material for extensive jawbone lesions. Further studies are needed to validate its long-term efficacy and safety.
