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Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
Published on: May 27, 2022
An interpretable clinical-proteomic framework identifies baseline neuroinflammatory proteomic patterns associated
Min Xiao1, Niu Qiao2, Ruihong Zhang2
1Shanghai Ji Ai Genetics and IVF Institute, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai, China.
Journal of Neuroinflammation
|July 19, 2026
Summary
Endovascular thrombectomy (EVT) shows poor outcomes linked to baseline inflammation and immune receptor patterns. Lower-risk patients had adhesion and extracellular matrix protein patterns, suggesting distinct biological pathways.
Area of Science:
- Neuroscience
- Biochemistry
- Immunology
Background:
- Endovascular thrombectomy (EVT) is standard for emergent large-vessel occlusion, but nearly 20% of patients die within one year.
- Early clinical indicators aid prognosis stratification, yet baseline neuroinflammatory biology linked to fatal EVT outcomes is poorly understood.
Purpose of the Study:
- To characterize baseline neuroinflammatory biology associated with fatal outcomes after EVT.
- To explore clinical-proteomic patterns correlating with patient risk strata post-EVT.
Main Methods:
- Prospective study of 148 EVT-treated patients, including 30 1-year non-survivors.
- Pre-procedure serum proteins profiled using the Olink 384 Inflammation panel.
- Exploratory clinical-proteomic framework applied, mapping clinical strata to proteomic patterns via differential expression.
Main Results:
- Higher-risk clinical phenotypes associated with baseline inflammation and immune-receptor-related protein patterns.
- Lower-risk clinical phenotypes associated with baseline adhesion and extracellular-matrix-related protein patterns.
- Identified distinct proteomic signatures correlating with clinical risk post-EVT.
Conclusions:
- Poor outcomes after EVT are associated with specific baseline inflammatory and tissue-structure-related proteomic patterns.
- Findings suggest a neuroinflammation-focused framework for hypothesis generation and candidate prioritization in EVT prognosis.
- Results require external validation to confirm clinical utility.