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Published on: March 12, 2018
Pulmonary metastasectomy: a 14-year single-center experience and literature review
Ramin Dabiri1, Ali Mehri1, Hossein Sadidi2
1Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Background:
Pulmonary metastasectomy (PM) is a commonly performed surgical procedure in selected patients with metastatic disease. The characteristics of patients undergoing PM and the spectrum of primary malignancies considered for surgical resection vary across institutions. We aim to provide a better understanding of current practice patterns by describing the characteristics and perioperative outcomes of patients who underwent PM at our institution.
Methods:
We conducted a retrospective descriptive study of patients who underwent pulmonary metastasectomy between 2008 and 2022 at Ghaem Hospital, Mashhad, Iran. Demographic and clinicopathological data, including age, sex, primary tumor type, histology, and postoperative outcomes, were collected and analyzed.
Results:
A total of 128 patients (mean age, 38.9 ± 18.0 years) were included in the analysis. The most common primary tumor sites were bone (25.8%) and soft tissue (16.4%), followed by head and neck (9.4%), colorectal (7.0%), and testicular (7.0%) malignancies. Sarcoma was the predominant histologic subtype (57.8%), followed by squamous cell carcinoma (11.7%), adenocarcinoma (10.9%), and germ cell tumors (7.8%). Postoperative complications included air leakage (n = 35), vascular injury requiring blood transfusion (n = 34), and one surgical site infection.
Conclusion:
Pulmonary metastasectomy is performed in patients with a wide range of primary malignancies, with sarcoma representing the most common indication in our cohort. Review of the literature suggests that the role of pulmonary metastasectomy varies across different primary malignancies and depends on careful patient selection. Further prospective studies are needed to better define the clinical utility of pulmonary metastasectomy in different tumor types.
Insights
Pulmonary metastasectomy (PM) is a surgical option for various cancers, most commonly sarcoma in this study. Outcomes vary, highlighting the need for careful patient selection and further research.
Area of Science:
- Thoracic Surgery
- Surgical Oncology
- Cancer Metastasis Research
Background:
- Pulmonary metastasectomy (PM) is a key procedure for selected patients with metastatic disease.
- Practice patterns and patient characteristics for PM vary significantly across healthcare institutions.
- Understanding institutional PM practices and outcomes is crucial for optimizing patient care.
Purpose of the Study:
- To characterize patient demographics and clinicopathological features of those undergoing PM.
- To analyze the perioperative outcomes and complication rates following PM.
- To contribute to a better understanding of current PM practice patterns.
Main Methods:
- Retrospective descriptive study design.
- Data collected from 128 patients undergoing PM between 2008-2022 at Ghaem Hospital, Iran.
- Analysis of demographic, clinicopathological, and postoperative outcome data.
Main Results:
- The most frequent primary tumor sites were bone (25.8%) and soft tissue (16.4%).
- Sarcoma was the predominant histology (57.8%), followed by squamous cell carcinoma and adenocarcinoma.
- Common postoperative complications included air leakage (35 patients) and vascular injury (34 patients).
Conclusions:
- Pulmonary metastasectomy is utilized for a diverse range of primary malignancies, with sarcoma being the most common indication in this cohort.
- The efficacy of PM varies by primary cancer type, emphasizing the importance of meticulous patient selection.
- Further prospective research is necessary to elucidate the precise clinical utility of PM across different tumor types.
