Related Experiment Video
Updated: Aug 6, 2026
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
Medullary thyroid carcinoma diagnosis based on microRNA analysis: a case report
Pranati P Borkhetaria1,2, Salmaan Sayeed3, Margaret Nurimba4,5
1THANC (Thyroid, Head & Neck Cancer) Foundation, New York, NY, USA. pranati.borkhetaria@thancfoundation.org.
Purpose:
Medullary thyroid cancer (MTC) is primarily diagnosed through calcitoninlevel analysis and RET mutation status. In their absence, MTC diagnosis may notoccur until after surgery, requiring a completion thyroidectomy after initial lobectomy.The authors present the first reported prospective case of MTC diagnostic suspiciondriven primarily by microRNA (miRNA) profiling.
Case Presentation:
A 42-year-old male with an incidentally found thyroid nodule underwent FNA, revealing Bethesda IV cytology. ThyGeNEXT® sequencing showedno mutations; ThyraMIR®v2 profiling demonstrated a 91% match pattern favoringMTC. Subsequent labs noted elevated calcitonin (273 pg/mL). The patient underwent total thyroidectomy and central neck dissection. Histology confirmed MTC with calcitonin, INSM1, and S100 protein positivity.
Conclusion:
This case demonstrates the potential of miRNA profiling as a stand-alonediagnostic adjunct in indeterminate thyroid nodules, highlighting its role in preventingdelayed diagnosis and improving surgical planning.
