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Recent Advances on Liquid-Phase Separation Techniques in Liquid Biopsy Technology for Detecting Circulating Cancer
Elif Burcu Aydın1, Muhammet Aydın1, Mustafa Kemal Sezgintürk2
1Scientific and Technological Research Center, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
Electrophoresis
|July 20, 2026
Summary
Liquid biopsy offers a minimally invasive approach for early cancer detection and treatment monitoring. This technique analyzes biomarkers in bodily fluids, improving diagnostic accuracy and patient outcomes.
Area of Science:
- Oncology
- Biotechnology
- Molecular Diagnostics
Background:
- Rising global cancer morbidity and mortality necessitate advanced diagnostic tools.
- Tissue biopsy limitations drive the need for less invasive cancer detection methods.
- Liquid biopsy emerges as a promising alternative for cancer assessment.
Purpose of the Study:
- To comprehensively review recent advancements (2005-2025) in liquid biopsy technology for cancer biomarker detection.
- To summarize the applications of liquid biopsy in early diagnosis, monitoring, and treatment response assessment.
- To discuss the role of specific biomarkers like circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA).
Main Methods:
- Review of scientific literature focusing on liquid biopsy applications and biomarker detection.
- Analysis of circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), microRNAs (miRNAs), exosomes, and autoantibodies.
- Examination of detection technologies, their challenges, and potential solutions.
Main Results:
- Liquid biopsy enables early cancer identification and treatment outcome prediction through analysis of biomarkers in blood and other bodily fluids.
- Identification of tumor-origin components like CTCs and ctDNA aids in disease monitoring and early recurrence detection.
- Advancements in analytical methods and informatics enhance diagnostic precision when combined with clinical data.
Conclusions:
- Liquid biopsy is a valuable tool for non-invasive cancer diagnosis, monitoring, and personalized treatment strategies.
- Further development in detection technologies and data analysis is crucial for optimizing liquid biopsy's clinical utility.
- Liquid biopsy holds significant potential for improving cancer care and patient outcomes globally.
