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Congo Red Unmasks the Culprit Behind Gastrointestinal Bleeding
Claire C Russell1, Khaleel Quasem2, Caleb M Glover2
1Internal Medicine, Michigan State University, Lansing, USA.
Cureus
|July 20, 2026
Summary
Gastrointestinal bleeding in immunoglobulin light chain (AL) amyloidosis is rare but serious. Early diagnosis via Congo red staining is crucial for patients with plasma cell disorders and unexplained bleeding.
Area of Science:
- Hematology
- Gastroenterology
- Pathology
Background:
- Immunoglobulin light chain (AL) amyloidosis involves extracellular deposition of misfolded light chains, stemming from plasma cell dyscrasias.
- Gastrointestinal (GI) involvement, though uncommon, poses significant risks due to amyloid-related mucosal ischemia and vascular fragility, potentially causing severe bleeding.
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