Clinical study to evaluate the effect of different types of dyslipidemia on left ventricular function based on...

To investigate the value of three-dimensional speckle-tracking echocardiography (3D-STE) in evaluating early left ventricular (LV) systolic function in patients with different types of dyslipidemia.

A total of 109 patients with dyslipidemia treated at our hospital were selected and divided into high total cholesterol (TC) group, high triglyceride (TG) group, low high-density lipoprotein cholesterol (HDL-C) group and mixed dyslipidemia group, according to the variety of dyslipidemia for further analysis.A total of 100 healthy volunteers approximately matched for age and gender were selected as the control group. The basic clinical data and conventional echocardiographic parameters were obtained, and the global longitudinal peak strain (GLPS), circumferential peak strain (GCPS) and radial peak strain (GRPS) of the left ventricle were obtained by 3D-STI technology for further analysis.

(1)The GLPS and GCPS of the high TC group, high TG group and low HDL-C group were lower than those of the control group, and the GLPS, GCPS and GRPS of the mixed dyslipidemia group were lower than those of the other groups. (2) The ROC curve analysis showed that the area under the curve (AUC) of GLPS for detecting dyslipidemia patients was the largest. (3) Linear regression analysis showed that GLPS was independently correlated with TC, LDL-C, TG, and HDL-C. The independent effect of LDL-C on GLPS (standardizedβ = -0.368) was stronger than that of TC (standardizedβ = -0.356), suggesting LDL-C has a greater impact on left ventricular longitudinal strain. (4)The Bland-Altman analysis showed that 3D-STE parameters had good intra-observer and inter-observer consistency.

Dyslipidemia had adverse effects on left ventricular strain parameters, especially in patients with mixed dyslipidemia. 3D-STE effectively evaluated the global systolic function of LV in patients with different types of dyslipidemia, and LDL-C shows the strongest independent effect correlating with worse systolic function.