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Updated: Aug 6, 2026
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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
Published on: July 6, 2022
Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics
Limin Zhang1, Zhiwei Yin1, Minxuan Wang2
1The University of Hong Kong Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen 518048, P. R. China.
Chemical Communications (Cambridge, England)
|July 20, 2026
Summary
This study introduces a novel nanoparticle drug delivery system combining sonodynamic therapy (SDT) and immune checkpoint blockade (ICB) for enhanced cancer treatment. Spatially resolved proteomics revealed the synergistic mechanism, overcoming limitations of current nanoparticle therapies.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Therapy
Background:
- Nanoparticle drug delivery systems often lack precise control over drug release and mechanism elucidation.
- Sonodynamic therapy (SDT) and immune checkpoint blockade (ICB) are promising cancer treatment modalities with potential for synergy.
Purpose of the Study:
- To develop a stimulus-responsive nanoparticle system for combined SDT and ICB.
- To investigate the synergistic therapeutic mechanism of this combined approach using advanced proteomics.
Main Methods:
- Design of a nanoparticle system incorporating targeted peptides and quantum dots (QDs).
- Application of spatially resolved proteomics to analyze treatment mechanisms.
- Evaluation of synergistic therapeutic effects in a relevant model.
Main Results:
- The developed system demonstrated effective drug delivery with improved spatiotemporal control.
- Spatially resolved proteomics identified key molecular pathways involved in the SDT-ICB synergy.
- The combined therapy showed enhanced anti-tumor efficacy compared to individual treatments.
Conclusions:
- The novel nanoparticle system successfully integrates SDT and ICB for synergistic cancer therapy.
- Understanding the mechanism through proteomics enables optimization of nanoparticle-based combination treatments.
- This approach offers a promising strategy for overcoming challenges in nanoparticle drug delivery and cancer treatment.
