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Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Iron-photocatalyzed decarboxylative allylation of aspartic and glutamic acid derivatives
Hongyao Li1, Yang Li1, Mengyang Dong1
1Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China. xinyaoli@shu.edu.cn.
Abstract:
Synthetic strategies for the selective chemical modification of natural amino acids and peptides are constantly in great demand in current state-of-the-art therapeutics. Herein, we present an iron-photocatalyzed decarboxylative coupling of aspartic and glutamic acid derivatives with Morita-Baylis-Hillman esters for the synthesis of allyl-modified unnatural amino acids and oligopeptides. Utilizing aspartic and glutamic acid derivatives as alkyl radical precursors, this strategy features a wide substrate scope, mild conditions, operational simplicity, and no requirement for substrate preactivation.
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