Preparation of Novel Naphthyl Thiazoles from Hydrazonoyl Halides

In this article, we designate the hydrazonoyl halides and thiosemicarbazone employed in the synthesis of novel naphthyl thiazoles.

Under reflux conditions and exclusion of water, thiosemicarbazone reacted with aldehydes to produce thiosemicarbazones. Aryl naphthyl-thiazoles are synthesized from the reaction of thiosemicarbazones with hydrazonoyl halides. In every case, the reaction yielded a specific product. This method is beneficial from a preparative perspective due to the cost-effectiveness and appropriateness of the reaction conditions, the purity of the products, the availability of the reagents in the market, and the favorable yields. As detailed in the experimental section, elemental analysis along with spectral data (MS, NMR, and FT-IR) was employed to elucidate the chemical structures of the final products.

The reaction between thiosemicarbazones and hydrazonoyl led to the formation of novel naphthyl thiazole compounds.

The description of this reaction begins with a nucleophilic attack followed by elimination of hydrochloric acid to produce the S-alkylated intermediate, which is followed by loss of water.

This approach will prove beneficial because of its low cost, simple reaction conditions, and the ready availability of the chemicals.