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Updated: Aug 6, 2026
![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Visible-Light Photoredox-Catalyzed Radical Addition/Double Cyclization of Indole with Alkenes: Access to
Zhen Yao1,2, Yuanyuan Wang1, Lifang Qi1
1School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang550025, China.
Abstract:
A visible-light photoredox-catalyzed one-pot tandem synthesis of gem-difluorotetrahydrocarbazolones from readily accessible N-alkenylindoles and ethyl bromodifluoroacetate (BrCF2CO2Et) has been developed. Notably, this protocol is also applicable to pyrrole-type substrates, enabling the efficient construction of the corresponding gem-difluorinated cyclic products. This transformation proceeds under ambient conditions, delivers high yields, shows outstanding functional group tolerance, and can be easily and conveniently scaled up to the gram level. The fac-[Ir(ppy)3] complex served as the key photocatalyst for this transformation.
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