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Photodynamic bone stabilization: a novel approach to elderly metastatic patients
R Totti1,2, F Cavola1,2, R M Comodo1,2
1Catholic University of the Sacred Heart, Milan, Italy.
Musculoskeletal Surgery
|July 20, 2026
Summary
Photodynamic Bone Stabilization (PBS) offers a minimally invasive option for treating metastatic bone fractures, showing reduced pain and improved function. While complications occurred, the preliminary results suggest promise for this oncologic patient group.
Area of Science:
- Orthopedic Surgery
- Oncology
- Biomaterials
Background:
- Metastatic bone fractures pose challenges, particularly in elderly cancer patients.
- Minimally invasive techniques are sought for fracture stabilization and faster recovery.
Purpose of the Study:
- To review outcomes and complications of Photodynamic Bone Stabilization (PBS) using the IlluminOss® System for metastatic bone fractures.
- To compare PBS with traditional intramedullary nailing methods.
Main Methods:
- A systematic review following PRISMA guidelines of five studies.
- Inclusion of 148 oncologic patients with metastatic bone fractures treated with PBS.
- Analysis of pain scores (VAS) and functional scores (MSTS) pre- and post-surgery.
Main Results:
- PBS demonstrated a significant reduction in mean VAS pain scores (7.71 to 4.19).
- Mean MSTS scores improved from 30.38% preoperatively to 61.59% postoperatively.
- Complications occurred in 18.24% of patients, including device rupture (9.45%).
Conclusions:
- Photodynamic Bone Stabilization (PBS) shows promising outcomes for metastatic bone fractures, with improved pain and function.
- While complications exist, PBS may offer advantages over traditional nailing, warranting further investigation.
- Randomized controlled trials are needed to confirm the superiority of PBS over current treatments.
