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Published on: August 13, 2017
Acidic nuclear phosphoprotein 32A (ANP32A): structure, function, and its role in disease pathogenesis
Zhiqi Zhang1, Enjie Liu1, Zeyuan Wang1
1Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Molecular Biology Reports
|July 20, 2026
Summary
Acidic nuclear phosphoprotein 32A (ANP32A) is a key protein regulating cellular functions and disease. This review explores its dual role in cancer, acting as both a tumor suppressor and oncogene, to guide targeted therapies.
Area of Science:
- Molecular Biology
- Cellular Biology
- Biochemistry
Background:
- Acidic nuclear phosphoprotein 32A (ANP32A) is a pleiotropic protein regulating cellular homeostasis and disease.
- ANP32A is a core component of the inhibitor of histone acetyltransferases (INHAT) complex.
- It plays critical roles in transcriptional regulation, apoptosis, and signal transduction.
Purpose of the Study:
- To systematically review the structure-function relationship of ANP32A.
- To elucidate ANP32A's role as a host factor in viral replication.
- To explore ANP32A's complex involvement in neurodegenerative diseases and oncology.
Main Methods:
- Systematic literature review.
- Analysis of ANP32A's structure-function dynamics.
- Examination of ANP32A's roles in various biological processes and diseases.
Main Results:
- ANP32A is an essential host factor for viral replication.
- ANP32A has a complex, context-dependent role in neurodegenerative processes.
- ANP32A exhibits a "double-edged sword" effect in oncology, acting as a tumor suppressor or oncogene.
Conclusions:
- Understanding ANP32A's structure-function relationship is crucial for its biological roles.
- ANP32A's multifaceted roles in viral, neurological, and oncological diseases warrant further investigation.
- This review provides a foundation for developing precision-targeted clinical interventions for ANP32A.
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