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Effects of Lifestyle Modification on Intrapancreatic Fat Deposition: A Systematic Review and Meta-Analysis
Saeed Ahmad1, Hyun Hee Sul2, Pojsakorn Danpanichkul3
1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Current Obesity Reports
|July 20, 2026
Summary
Lifestyle modification significantly reduces intrapancreatic fat deposition (IPFD), a key factor in pancreatic diseases. Combined diet and exercise interventions showed the greatest numerical impact, supporting structured programs for pancreatic health.
Area of Science:
- Metabolic Health
- Pancreatic Diseases
- Lifestyle Medicine
Background:
- Intrapancreatic fat deposition (IPFD) is increasingly recognized as crucial in endocrine and exocrine pancreatic diseases.
- Existing literature on lifestyle modification's impact on IPFD requires systematic synthesis.
Purpose of the Study:
- To conduct a systematic review and meta-analysis assessing the effects of lifestyle modification on intrapancreatic fat deposition (IPFD).
Main Methods:
- Systematic literature search in PubMed and Embase for interventional studies.
- Magnetic resonance-based techniques used for IPFD measurement.
- Meta-analysis using a random-effects model; heterogeneity and publication bias assessed.
Main Results:
- 23 studies included; lifestyle modification significantly reduced IPFD (SMD -0.26).
- Pooled absolute reduction in MRI-measured IPFD was -1.02%, with low heterogeneity.
- Combined diet-and-exercise interventions showed the largest numerical IPFD reduction, though not statistically significant between types.
Conclusions:
- Lifestyle modification is an effective non-pharmacological strategy for reducing IPFD.
- Structured lifestyle programs, particularly combined diet and exercise, show promise for managing pancreatic fat and disease.
- Findings support lifestyle interventions for the prevention and management of pancreatic diseases.
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