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A Precision Medicine Framework to Improve Patient Care Using Orthobiologics
Daniel de la Huerta Meza1, Purva Singh1, Miguel Otero1,2
1Hospital for Special Surgery, New York, NY.
The Journal of Bone and Joint Surgery. American Volume
|July 20, 2026
Summary
Precision medicine offers a solution to inconsistent treatment responses in orthopaedics. Tailoring therapies like orthobiologics to individual patients can improve clinical efficacy and patient outcomes.
Area of Science:
- Orthopaedic surgery
- Regenerative medicine
- Biotechnology
Background:
- Traditional one-size-fits-all treatments lead to variable patient responses.
- Heterogeneity in patient populations and treatments challenges orthopaedic care.
- Inconsistent clinical efficacy of orthobiologics necessitates a new approach.
Purpose of the Study:
- To explore the implementation of precision medicine in orthopaedics.
- To address the challenges and opportunities in using orthobiologics.
- To improve patient care through tailored therapeutic strategies.
Main Methods:
- Review of current precision medicine initiatives.
- Analysis of patient and treatment variability in orthopaedics.
- Discussion of proposed frameworks for precision orthobiologics.
Main Results:
- Precision medicine can refine treatment allocation for orthopaedic conditions.
- Addressing patient and treatment variability is key to enhancing orthobiologic efficacy.
- A framework for precision medicine in orthopaedics is proposed.
Conclusions:
- Implementing precision medicine is crucial for optimizing orthobiologic treatments.
- Personalized approaches are needed to overcome heterogeneity in orthopaedic care.
- Future strategies should focus on patient stratification and treatment individualization.
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