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Assessing Prostaglandin-Analog-Associated Uveitis in Childhood Glaucoma
Marina B Zakhary Gad El Sayed1, Reem H ElSheikh2, Javaneh Abbasian3,4
1School of Medicine, University of California, Riverside, California, USA.
Ocular Immunology and Inflammation
|July 20, 2026
Summary
Prostaglandin analogues (PGAs) did not increase uveitis risk in pediatric glaucoma patients. In fact, PGAs showed a lower hazard of uveitis compared to beta-blockers and carbonic anhydrase inhibitors.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Glaucoma is a leading cause of irreversible blindness in children.
- Prostaglandin analogues (PGAs) are commonly used to manage glaucoma.
- The risk of uveitis associated with PGA use in pediatric glaucoma patients is not well-established.
Purpose of the Study:
- To evaluate the association between prostaglandin analogue (PGA) use and the development of uveitis in children and young adults with glaucoma.
Main Methods:
- Retrospective cohort study using the TriNetX US Collaborative Network.
- Included patients ≤20 years with glaucoma, excluding those with prior uveitis.
- Compared new initiation of PGAs versus topical beta-blockers or carbonic anhydrase inhibitors (CAIs) with 180-day follow-up.
Main Results:
- PGA initiation was associated with a significantly lower hazard of uveitis compared to beta-blockers (aHR 0.20; 95% CI, 0.14-0.29).
- Carbonic anhydrase inhibitor initiation showed no significant difference in uveitis hazard compared to beta-blockers (aHR 0.69; 95% CI, 0.46-1.04).
- Increasing age increased uveitis hazard, while male sex and aphakia decreased it.
Conclusions:
- Prostaglandin analogues (PGAs) do not increase the hazard of uveitis in pediatric glaucoma patients within 180 days.
- PGAs demonstrated a lower hazard of uveitis compared to beta-blockers and carbonic anhydrase inhibitors in this population.
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