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Platelet count at diagnosis predicts survival in children with acute lymphoblastic leukemia
Víctor H Olivares-Villalpando1,2, José G Peñaloza-González1, Martha M Velázquez-Aviña1
1Servicio de Onco Hemato Pediatría, Hospital Juárez de México, Secretaría de Salud.
Insights
In pediatric acute lymphoblastic leukemia, a higher initial platelet count is linked to improved survival. This finding is independent of other known prognostic factors, aiding in risk stratification.
Area of Science:
- Pediatric Oncology
- Hematology
- Leukemia Research
Background:
- Prognostic variables in pediatric acute lymphoblastic leukemia (ALL) guide treatment strategies.
- Risk stratification is crucial for optimizing patient outcomes in ALL.
Purpose of the Study:
- To determine the association between initial platelet count and survival in pediatric ALL patients.
- Investigate the prognostic value of platelet count at diagnosis.
Main Methods:
- Comparative survival analysis of pediatric ALL patients based on initial platelet count.
- Utilized Kaplan-Meier curves and Cox regression analysis.
- Defined a cut-off of 50 × 10^9/L for platelet count groups.
Main Results:
- Higher initial platelet counts (> 50 × 10^9/L) correlated with a better prognosis (p=0.002).
- Multivariate Cox regression confirmed initial platelet count as an independent predictor of overall survival (p=0.025, HR: 1.42).
Conclusions:
- Initial platelet count is a significant, independent prognostic factor in pediatric ALL.
- Platelet count at diagnosis directly impacts patient survival.
- This marker can refine risk assessment and treatment planning for childhood ALL.
Background:
The identification of prognostic variables in children with acute lymphoblastic leukemia has allowed the design of different treatment regimens according with the estimated risk of relapse of the disease in each patient.
Objective:
To associate the initial platelet count with survival in pediatric patients with acute lymphoblastic leukemia.
Material And Methods:
The survival of two groups of pediatric patients with acute lymphoblastic leukemia was compared, divided considering the platelet count that each patient had at the time of the onset of leukemia; a platelet count of 50 × 109/L was chosen as the cut-off point for the division into groups. Kaplan-Meier survival curves and Cox regression were used for the analysis.
Results:
A platelet count > 50 × 109/L predicted a better prognosis in children with acute lymphoblastic leukemia, with p = 0.002 in the bivariate analysis (Kaplan-Meier log rank). The multivariate analysis with Cox regression identifies the initial platelet count as a predictor of overall survival, with p = 0.025 (HR: 1.42; 95% CI: 1.15-4.47)).
Conclusions:
The platelet count at diagnosis is directly associated with survival independently of the other prognostic factors described.
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