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UBE2C at the crossroads of cell cycle regulation and DNA damage response in cancer

Sayandrila Paul1, Amoolya Kandettu1, Sanjiban Chakrabarty2

  • 1Department of Public Health Genomics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.

Cell Biology and Toxicology
|July 20, 2026
PubMed

Insights

The ubiquitin-proteasome system (UPS) enzyme UBE2C is overexpressed in many cancers, driving tumor growth and treatment resistance. Targeting UBE2C and its regulators offers promising new cancer therapies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • The ubiquitin-proteasome system (UPS) regulates critical cellular processes like DNA repair and cell cycle progression.
  • UBE2C, a ubiquitin-conjugating enzyme, is crucial for ubiquitylation of key cellular regulators.
  • UBE2C overexpression is prevalent in various carcinomas, correlating with aggressive tumor phenotypes and therapeutic resistance.

Purpose of the Study:

  • To review the mechanistic role of UBE2C in diverse cancers.
  • To highlight UBE2C's involvement in DNA damage repair via the anaphase-promoting complex (APC/C).
  • To explore the therapeutic potential of targeting UBE2C and its miRNA regulators (miR-381, miR-503, miR-205).

Main Methods:

  • Literature review focusing on UBE2C's function in cancer.
  • Analysis of UBE2C's role in DNA repair pathways.
  • Examination of miRNA-mediated regulation of UBE2C.

Main Results:

  • UBE2C overexpression is linked to tumor aggressiveness, genomic instability, epithelial-to-mesenchymal transition, and resistance to therapies.
  • UBE2C plays a significant role in DNA damage repair processes.
  • Specific miRNAs (miR-381, miR-503, miR-205) regulate UBE2C expression, suggesting therapeutic avenues.

Conclusions:

  • UBE2C is a potential biomarker and therapeutic target in multiple cancer types.
  • Understanding UBE2C's role in cell cycle regulation and DNA repair is key for developing novel diagnostics and precision medicine strategies.
  • Targeting UBE2C and its miRNA regulators shows promise for innovative cancer treatments.
Keywords:
CancerCell cycleDNA repairTumour progressionUBE2CUbiquitination

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