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Ligand relay catalysis enables asymmetric migratory dearomative annulation of N-heteroarenes
Zhiyong Song1, Xinyu Li1, Xinchen Wang1
1State Key Laboratory of Coordination Chemistry, Engineering Research Center of Photoresist Materials Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Abstract:
Chiral N-spiroheterocycles are privileged yet synthetically challenging scaffolds for ligands, functional materials, and drug discovery. Here we show a cobalt-catalyzed asymmetric migratory dearomative annulation of electron-deficient N‑heteroarenes for their construction. The success of this transformation hinges on a dynamic ligand relay catalysis strategy, wherein two distinct ligands work in tandem: one facilitates a 1,4-cobalt/hydride shift, and the other governs the enantioselective dearomative annulation, delivering chiral N-spiroheterocycles with high efficiency and selectivity.
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