Related Experiment Video
Updated: Aug 6, 2026
06:08
Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
Lacticaseibacillus rhamnosus OF44 alleviates allergic rhinitis by rebalancing host immunity and gut microbial
Liehai Hu1,2, Bin Hou3, Songci Yan3
1State Key Laboratory of Analytical Chemistry for Life Science-& Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital Group Suqian Hospital, Suqian Scientific Research Institute of Nanjing University Medical School, Medical School, Nanjing University, Nanjing, Jiangsu, 210093, China.
NPJ Science of Food
|July 20, 2026
Summary
Lacticaseibacillus rhamnosus OF44, a novel probiotic, effectively reduced allergic rhinitis symptoms in rats by rebalancing gut microbes and immune responses. This strain shows promise for managing allergic diseases through gut microbiome modulation.
Area of Science:
- Immunology
- Microbiology
- Gastroenterology
Background:
- Allergic rhinitis (AR) is linked to immune system imbalance and gut dysbiosis.
- Type 2 inflammation drives AR pathology.
Purpose of the Study:
- To investigate the potential of Lacticaseibacillus rhamnosus OF44 as a probiotic for allergic rhinitis.
- To elucidate the mechanisms by which OF44 modulates the gut microbiome and immune system.
Main Methods:
- Ovalbumin-induced allergic rhinitis rat model.
- Assessment of allergic symptoms, serum/nasal immunoglobulin and cytokine levels.
- Flow cytometry for immune cell populations (Th1/Th2/Th17/Treg).
- Metagenomic and functional profiling of gut microbiota.
Main Results:
- OF44 administration significantly reduced AR symptoms and normalized immune markers.
- Restored balance in Th1/Th2/Th17/Treg cell populations.
- OF44 enriched beneficial gut bacteria (Rikenellaceae, Alistipes) and suppressed Enterobacteriaceae.
- Reversed pro-inflammatory pathways and restored beneficial metabolic pathways, including SCFA production.
Conclusions:
- Lacticaseibacillus rhamnosus OF44 attenuates allergic rhinitis by reprogramming gut microbial composition and function.
- Mechanistic insights support OF44's application as a functional probiotic for allergic disease management.
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