[Clinical efficacy of high-frequency electromagnetic wave (radiofrequency) therapy for high-grade vaginal...

To analyze the clinical efficacy of high-frequency electromagnetic wave therapy for high-grade vaginal intraepithelial neoplasia (VaIN Ⅱ and Ⅲ) and its advantages over high-frequency electrosurgery. A retrospective study was conducted on 72 patients who underwent colposcopy-guided biopsy in the Department of Gynecology, Guizhou Provincial People's Hospital from January 2020 to June 2023 and were histologically diagnosed with VaIN Ⅱ and Ⅲ. The patients were divided into a high-frequency electromagnetic wave radiofrequency therapy group (observed group, 42 cases) and a high-frequency electrosurgery group (control group, 30 cases) according to the treatment they received. The age of the control group was 52 (42, 61) years, and that of the observed group was 49 (39, 60) years. Follow-ups were conducted at 1, 3, 6, 12, 18, and 24 months after treatment. The overall cure rate, therapeutic efficacy by lesion grade and location, wound healing time, and intraoperative and postoperative adverse reactions were compared between the two groups. Additionally, the effects of different treatment ranges and power parameters on efficacy in the observed group were analyzed, and changes in HPV clearance rates were compared between the two groups. The results showed that within 24 months, the overall cure rate in the observed group was 71.4% (30 cases), which was higher than that in the control group (46.7%, 14 cases) (P=0.034). The cure rate for vaginal sidewall lesions in the observed group was higher than that in the control group (84.6% vs 63.0%, P=0.042). Wound healing time was shorter in the observed group than in the control group (1.64 vs 2.67 months) (P=0.002). No intraoperative or postoperative bleeding occurred in the observed group, while 5 cases (16.7%) of bleeding occurred in the control group. High-frequency electromagnetic wave radiofrequency therapy has good clinical efficacy for high-grade VaIN. Compared with high-frequency electrosurgery, it offers more significant advantages in improving the cure rate, promoting wound healing, and reducing intraoperative and postoperative bleeding, demonstrating good clinical application value.