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Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes
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The relative immunogenicity of 20-valent and 15-valent pneumococcal conjugate vaccines: A systematic review and

Ilaria Valentini1,2, Erika Alessandra Strangi3, Gaia Baccarini2

  • 1Graduate School of Health Economics and Management (ALTEMS), Università Cattolica del Sacro Cuore, Rome, Italy.

Human Vaccines & Immunotherapeutics
|July 21, 2026
PubMed

Insights

Pneumococcal conjugate vaccines (PCV) comparisons in adults show PCV15 elicits stronger immune responses than PCV20 for most shared serotypes, particularly in older adults. Further direct comparative studies are recommended.

Area of Science:

  • Immunology
  • Vaccinology
  • Public Health

Background:

  • Pneumococcal conjugate vaccines (PCV) are crucial for preventing pneumococcal disease in adults.
  • Higher-valent PCVs aim to broaden protection, but direct comparisons between PCV20 and PCV15 in adults are lacking.

Conclusions:

  • PCV15 appears to elicit a more robust immune response than PCV20 for most shared serotypes in adults.
  • Age-stratified analyses suggest PCV15 may offer greater benefits for older adults.
  • Direct comparative trials and real-world effectiveness studies are needed to confirm these findings.

Keywords:
PCV15PCV20Pneumococcal conjugate vaccineadultsimmunogenicitynetwork meta-analysisopsonophagocytic activity

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