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Multimodal Fluorescent MOF@BODIPY Platform: Bridging Sensing and Mechanistic Insight
Alejandro Cortés-Villena1,2, Paula Rodrigo-Martínez3, José A Sáez3
1Department of Analytical Chemistry, University of Valencia, Burjassot, Valencia, Spain.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|July 21, 2026
Summary
We developed a novel hybrid metal-organic framework (MOF) sensor, MOF@BODIPY, for dual-channel optical detection. This advanced material offers high sensitivity for detecting Fe³⁺ ions, paving the way for next-generation environmental sensors.
Area of Science:
- Materials Science
- Nanotechnology
- Chemical Sensing
Background:
- Hybrid metal-organic frameworks (MOFs) with organic chromophores offer tunable photophysics for optical sensing.
- Photoresponsive chromophores in MOFs enable sensitive detection of guest-framework interactions via luminescence.
Purpose of the Study:
- To develop a hybrid luminescent platform (MOF@BODIPY) based on UiO-66-NH₂ functionalized with BODIPY dyes for advanced optical sensing.
- To create a dual-channel excitation system for simultaneous quantitative detection and mechanistic photophysical insights.
Main Methods:
- Covalent functionalization of UiO-66-NH₂ MOF with BODIPY dyes.
- Utilizing dual-channel excitation at 400 nm (MOF scaffold) and 500 nm (BODIPY chromophore).
- Employing fluorescence spectroscopy and time-resolved fluorescence spectroscopy for analysis.
Main Results:
- MOF@BODIPY demonstrated strong fluorescence quenching for Fe³⁺ detection with a limit of detection as low as 0.07 µM.
- Excitation of the MOF scaffold showed fluorescence enhancement, indicating coordination-driven suppression of nonradiative pathways.
- Time-resolved spectroscopy confirmed static quenching at the dye level and dynamic modulation within the MOF framework.
Conclusions:
- The hybrid MOF@BODIPY platform exhibits high sensitivity and dual optical functionality for multimodal sensing.
- Low-cost synthesis and synergistic interactions position this material as a versatile proof-of-concept for environmental optical sensors.
