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Twenty-year trends in paediatric cardiovascular mortality in the United States

Shahnawaz Amdani1, Amy E Cassedy2, Bradley S Marino1

  • 1https://ror.org/03xjacd83Children's Institute Department of Heart, Vascular and Thoracic, Division of Cardiology and Cardiovascular Medicine Cleveland Clinic Children's, Cleveland, OH, USA.

Cardiology in the Young
|July 21, 2026
PubMed

Insights

Paediatric cardiovascular mortality in the US significantly declined between 2003 and 2023. Reductions were observed across all geographic regions and demographic groups, indicating improved equity in child heart health outcomes.

Area of Science:

  • Cardiovascular Health
  • Epidemiology
  • Public Health

Background:

  • Paediatric cardiovascular diseases remain a significant public health concern.
  • Understanding trends in paediatric cardiovascular mortality is crucial for targeted interventions.
  • Geographic and demographic disparities in healthcare outcomes require continuous evaluation.

Purpose of the Study:

  • To analyze trends in paediatric cardiovascular mortality across the United States from 2003 to 2023.
  • To investigate geographic and demographic variations in these mortality trends.
  • To assess the equity of paediatric cardiovascular outcomes.

Main Methods:

  • Utilized data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database.
  • Conducted a comprehensive epidemiological analysis of paediatric cardiovascular mortality rates.
  • Examined trends across different county types (metropolitan vs. nonmetropolitan) and demographic subgroups (age, sex, race/ethnicity).

Main Results:

  • Overall paediatric cardiovascular mortality decreased from 4.73 to 3.17 per 100,000 population.
  • Mortality reductions were consistent across large metropolitan, medium/small metropolitan, and nonmetropolitan counties.
  • Declines in mortality were observed across various age, sex, and racial/ethnic groups, suggesting no significant rural-urban disparities.

Conclusions:

  • Paediatric cardiovascular mortality has declined significantly in the US over two decades.
  • Geographic and demographic factors did not show disparities in these positive mortality trends.
  • Findings highlight increasing geographic equity in paediatric cardiovascular health outcomes.

Keywords:
CDC WONDER databasePaediatriccardiovascular diseasemortality trends

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