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Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case
Shoshana Greenberger1,2, Efrat Bar-Ilan1,2, Victoria Marcu3
1Pediatric Dermatology Unit, Department of Dermatology, Sheba Medical Center, Ramat Gan, Israel.
None:
Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30-positive T-cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin-limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel PICALM::JAK2 fusion not previously described in pcALCL. Clinical courses ranged from spontaneous regression to systemic therapy, yet all achieved durable complete remission without progression over 31-50 months. These findings highlight previously unrecognized genomic diversity and expand the molecular landscape of pediatric pcALCL.