Related Experiment Video

Updated: Aug 6, 2026

An In Vitro Enzymatic Assay to Measure Transcription Inhibition by Gallium(III) and H3 5,10,15-tris(pentafluorophenyl)corroles
09:00

An In Vitro Enzymatic Assay to Measure Transcription Inhibition by Gallium(III) and H3 5,10,15-tris(pentafluorophenyl)corroles

Published on: March 18, 2015

The CoREST complex inhibitor, corin, decreases tumor growth, increases cellular differentiation and extends lifespan

Anupa Geethadevi1, Nikhil Vaidya2, Robert J Fisher2

  • 1Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, MD, USA 21205.

Neuro-Oncology
|July 21, 2026
PubMed
Abstract

Insights

The CoREST inhibitor corin effectively suppressed atypical teratoid rhabdoid tumor (ATRT) growth, promoting differentiation and apoptosis. This drug significantly improved survival in ATRT mouse models, suggesting therapeutic potential.

Area of Science:

  • Oncology
  • Epigenetics
  • Chromatin Biology

Background:

  • Atypical teratoid rhabdoid tumor (ATRT) is a common infant brain malignancy linked to SMARCB1 loss.
  • SMARCB1 inactivation disrupts SWI/SNF chromatin remodeling, impacting the CoREST repressor complex.
  • The CoREST complex's role in ATRT tumorigenesis warrants investigation.

Purpose of the Study:

  • To investigate the therapeutic potential of targeting the CoREST complex in ATRT.
  • To evaluate the effects of the CoREST inhibitor corin on ATRT cells and models.

Main Methods:

  • Assessed corin's impact on ATRT cell growth, apoptosis, differentiation, and gene expression.
  • Utilized ATAC-seq and RNA-seq to analyze chromatin accessibility and gene expression changes.
  • Evaluated corin's efficacy in orthotopic ATRT xenograft mouse models.

Main Results:

  • Corin inhibited ATRT cell growth, induced apoptosis and differentiation across epigenetic subgroups.
  • Corin treatment increased chromatin accessibility and neuronal gene expression.
  • Corin suppressed tumor growth and extended lifespan in ATRT mouse models, with on-target pharmacodynamic effects.

Conclusions:

  • The CoREST inhibitor corin demonstrates significant anti-tumor activity in ATRT.
  • Corin suppressed tumor growth, induced differentiation, and promoted apoptosis, improving survival in mouse models.
  • CoREST complex inhibitors represent a promising therapeutic strategy for ATRT patients.
Keywords:
LSD1SWI/SNFepigenetic reprogrammingneuronal differentiationrhabdoid

More Related Videos

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...