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Updated: Aug 6, 2026

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
Published on: May 2, 2018
An NLR-VOZ seesaw: from asymmetric selection to synthetic broad-spectrum resistance
Yachun Su1, Shoujian Zang1, Tingting Sun2
1Key Laboratory of Sugarcane Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, National Engineering Research Center for Sugarcane, College of Agriculture, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Abstract:
A recent study in Nature identified the rice (Oryza sativa) nucleotide-binding site and leucine-rich repeat (NLR) receptor XA48, which recognized the ancient bacterial effector XopG and triggered immunity by promoting degradation of the negative regulators OsVOZ1/2. Population genomics revealed an asymmetric selection, with Xa48 retained in indica but lost in japonica due to a reproductive penalty. By stacking XA48-mediated effector-triggered immunity (ETI) with XA21-mediated pattern-triggered immunity (PTI) and introducing the compatible OsVOZ1S allele, broad-spectrum bacterial blight resistance from wild rice was reconstituted. This work provides a design strategy that helps break the growth-defence trade-off.
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