Related Experiment Video
Updated: Aug 6, 2026
07:40
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
A 59-year-old woman with refractory uveitis
Lisa R Koenig1, Eli L Diamond2, Jasmine H Francis1
1Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Retinal Cases & Brief Reports
|July 21, 2026
Summary
Ophthalmic artery chemosurgery (OAC) with melphalan offers a novel, durable treatment for refractory Rosai-Dorfman-Destombes disease (RDD) manifesting in the eye. This approach led to sustained resolution of ophthalmic symptoms and maintained visual acuity over four years.
Area of Science:
- Ophthalmology
- Oncology
- Dermatology
Background:
- Rosai-Dorfman-Destombes disease (RDD) can present with challenging ophthalmic manifestations.
- Refractory cases require innovative treatment strategies.
Purpose of the Study:
- To report a novel application of melphalan via ophthalmic artery chemosurgery (OAC) for ophthalmic RDD.
- To assess the durability of this treatment approach.
Main Methods:
- A case report detailing the treatment of a patient with RDD.
- Administration of cobimetinib and melphalan via OAC.
Main Results:
- Successful management of ophthalmic RDD presenting as uveitis and scleritis.
- Sustained resolution of ophthalmic manifestations and 20/20 visual acuity at four-year follow-up.
Conclusions:
- OAC melphalan represents a novel and effective treatment for ophthalmic RDD.
- This therapeutic strategy demonstrates durable efficacy in managing ocular manifestations of RDD.
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