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Updated: Aug 6, 2026
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Clinical Imaging of Microwave Mammography
Published on: November 14, 2025
Contrast-Enhanced Mammography for Breast Cancer Screening: A Systematic Review and Meta-Analysis
Komal Verma Saluja1, Sangeeta Saxena1, Harshvardhan Khokhar1
1Department of Radiology, Government Medical College, RUHS, Kota, Rajasthan, India.
Journal of Breast Imaging
|July 21, 2026
Summary
Contrast-enhanced mammography (CEM) significantly increases cancer detection by 9.3 cases per 1,000 women compared to low-energy mammography. CEM shows comparable cancer detection to MRI in select screening contexts, informing clinical implementation.
Area of Science:
- Radiology and Imaging
- Oncology
- Public Health
Background:
- Mammography is a cornerstone of breast cancer screening.
- Limitations exist in detecting cancers with low-energy mammography.
- Emerging technologies like contrast-enhanced mammography (CEM) warrant evaluation.
Purpose of the Study:
- To evaluate pathway-specific cancer detection for CEM.
- To summarize screening outcomes for CEM.
- To compare CEM with low-energy mammography and breast MRI.
Main Methods:
- Systematic review and meta-analysis following PRISMA guidelines.
- Searched PubMed, Embase, Scopus, Web of Science (2011-2025).
- Included screening/surveillance studies; excluded diagnostic/recall studies.
Main Results:
- CEM detected 9.3 additional cancers per 1,000 women versus low-energy mammography (RD, +9.3; P < 0.01).
- Seven studies contributed to meta-analysis; 14 studies for qualitative synthesis.
- CEM cancer detection may be comparable to MRI in select settings, but limited data exists.
Conclusions:
- CEM improves cancer detection compared to low-energy mammography in screening and surveillance.
- CEM shows potential comparability to MRI, but more research is needed.
- Findings can inform clinical implementation and future screening trial designs.
