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Chronic postsurgical pain: risk assessment and mitigation
Martin D Cheatle1,2, Isabella Rosales3, Kai-Hua Chang3
1Departments of Psychiatry.
Current Opinion in Anaesthesiology
|July 21, 2026
Summary
Chronic postsurgical pain (CPSP) and persistent postoperative opioid use (PPOU) are common after surgery. Modifiable risk factors like distress and opioid exposure can be mitigated through psychological interventions and opioid sparing.
Area of Science:
- Anesthesiology and Pain Management
- Surgical Complications Research
Background:
- Chronic postsurgical pain (CPSP) and persistent postoperative opioid use (PPOU) are significant complications following surgery.
- These conditions lead to substantial personal and economic burdens.
Purpose of the Study:
- To review identified and potential risk factors for CPSP and PPOU.
- To outline strategies for mitigating these risk factors.
Main Methods:
- Literature review of known risk factors for CPSP and PPOU.
- Analysis of evidence-based mitigation strategies.
Main Results:
- Modifiable risk factors for CPSP include psychological distress, preoperative pain, and perioperative opioid exposure.
- Psychological comorbidities are also identified as risk factors for PPOU.
- Psychological interventions and opioid-sparing techniques are evidence-based mitigation strategies.
Conclusions:
- Anesthesiologists must recognize perioperative risk factors for CPSP and PPOU.
- Further prospective studies are needed to develop practical, evidence-based interventions to reduce CPSP and PPOU incidence.
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