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Updated: Aug 6, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

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Published on: March 2, 2014

Soluble triggering receptor expressed on myeloid cells 2 restrained PRRSV replication via interfering PRRSV binding

Zhenbang Zhu1, Meng Zhang1, Yuqian Xu1

  • 1Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, PR China; Jiangsu Interdisciplinary Center for Zoonoses and Biosafety, Yangzhou University, Yangzhou 225009, PR China; Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, PR China.

Veterinary Microbiology
|July 21, 2026
PubMed
Summary

Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) inhibits porcine reproductive and respiratory syndrome virus (PRRSV) replication. This study reveals sTREM2 binds PRRSV GP2a, blocking viral entry and activating immune pathways for potential clinical applications.

Keywords:
Antiviral mechanismNF-ĸB signaling pathwayPRRSVProinflammatory cytokinesSoluble TREM2

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