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Frontal and temporal hyper-perfusion in Parkinson's disease with subjective cognitive decline
Kiyoaki Takeda1, Atsushi Shima2, Akira Nishida1
1Department of Neurology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawaharacho, Kyoto, 606-8507, Japan.
Parkinsonism & Related Disorders
|July 21, 2026
Summary
Parkinson's disease with subjective cognitive decline (PD-SCD) shows increased cerebral blood flow (CBF) in frontal and temporal regions. This may indicate compensatory mechanisms in early-stage Parkinson's disease cognitive changes.
Area of Science:
- Neuroimaging
- Neurology
- Cognitive Science
Background:
- Parkinson's disease with subjective cognitive decline (PD-SCD) is linked to higher risks of mild cognitive impairment (PD-MCI) and dementia.
- Cerebral blood flow (CBF) imaging can reveal functional changes preceding cognitive decline.
Purpose of the Study:
- To characterize regional CBF patterns in PD-SCD.
- To compare CBF patterns in PD-SCD with those in Parkinson's disease with normal cognition (PD-NC) and PD-MCI.
Main Methods:
- 140 Parkinson's disease patients were categorized into PD-NC (n=32), PD-SCD (n=31), or PD-MCI (n=77) using MDS criteria.
- Participants underwent clinical evaluation, depression assessment, MRI, and 123I-iodoamphetamine SPECT.
- Statistical parametric mapping analyzed whole-brain voxel-wise tracer uptake ratios, adjusting for covariates.
Main Results:
- PD-SCD exhibited significantly increased CBF in bilateral frontal and temporal regions and the left cerebellum compared to PD-NC.
- PD-MCI showed bilateral frontal and temporal hypo-perfusion relative to PD-SCD.
- These findings were corrected for multiple comparisons (family-wise error).
Conclusions:
- PD-SCD is associated with hyper-perfusion in frontal and temporal regions compared to PD-NC and PD-MCI.
- These hyper-perfused areas overlap with regions susceptible to degeneration in PD dementia.
- This suggests compensatory network responses in PD-SCD.
Keywords:
Cerebral blood flow (CBF)Compensatory mechanismsDementiaMild cognitive impairment single-photon emission computed tomography (SPECT)More Related Videos
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