Related Experiment Video
Updated: Aug 6, 2026

Rapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory Drugs
Published on: December 27, 2016
Cell volume control as a key regulator of immune cell function
Anusuya Hubert-Tulasi1, Lina Liu1, Robert Köchl1
1Peter Gorer Department of Immunobiology, King's College London, London, SE1 9RT, UK.
Immune cell volume changes, driven by ion transport, impact immune functions like migration and activation. Understanding these volume regulatory mechanisms is crucial for immune cell research.
Area of Science:
- Immunology
- Cell Biology
- Physiology
Background:
- Immune cells encounter diverse environments influencing their volume.
- Cell volume changes, mediated by ion channels and transporters, are linked to immune cell functions.
- Neutrophils, macrophages, dendritic cells, and T cells are key immune cells studied for volume regulation.
Purpose of the Study:
- To review mechanisms of immune cell volume regulation.
- To examine the link between cell volume changes and immune cell behavior.
- To highlight limitations in current volume measurement techniques.
Main Methods:
- Literature review of existing studies on immune cell volume regulation.
- Focus on experimental evidence for neutrophils, macrophages, dendritic cells, and T cells.
- Discussion of approaches to measure cell volume.
Main Results:
- Cell volume regulation is a significant factor in immune cell migration, activation, and proliferation.
- Environmental factors actively influence immune cell volume, impacting function.
- Direct measurement of cell volume is underutilized, limiting current understanding.
Conclusions:
- Cell volume regulation plays an active role in immune cell function.
- Further research using direct volume measurements is needed to advance understanding.
- Understanding volume changes is key to deciphering immune cell behavior.
More Related Videos
07:17Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
08:06Determination of Regulatory T Cell Subsets in Murine Thymus, Pancreatic Draining Lymph Node and Spleen Using Flow Cytometry
Published on: February 27, 2019
Related Concept Videos
Regulation of Hematopoietic Stem Cells
Cells of the Adaptive Immune Response
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Functions of the Lymphatic and Immune System
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Immune Surveillance by NK Cells and Phagocytes
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...