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Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
Breast Cancer Location Predicts Sentinel Lymph Node Metastasis in Clinically Node Negative Patients With Invasive
Nazia Riaz1, Nizar AbuOddus2, Hafsteinn Peturson3
1Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden; Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
Clinical Breast Cancer
|July 21, 2026
Summary
Tumor location in the breast independently predicts sentinel lymph node (SLN) metastasis in node-negative breast cancer patients. Considering cancer location aids in selecting patients for de-escalated axillary surgery.
Area of Science:
- Oncology
- Surgical Oncology
- Breast Cancer Research
Background:
- Clinicopathological factors are standard for predicting sentinel lymph node (SLN) status in node-negative breast cancer.
- The role of cancer location as an independent predictor of SLN status is understudied.
Purpose of the Study:
- To evaluate clinicopathological factors, particularly tumor location, in predicting SLN status in invasive breast cancer patients.
Main Methods:
- Retrospective analysis of 1231 patients with T1-T3 node-negative invasive breast cancer.
- All patients underwent SLN biopsy.
- Multivariable logistic regression assessed predictors of SLN metastasis, including tumor location.
Main Results:
- 17.6% of patients had positive SLN metastasis.
- Age, tumor size, and tumor location (inferior-lateral and superior-medial quadrants) were significant predictors of SLN status.
Conclusions:
- Breast tumor location is an independent risk factor for SLN metastasis.
- Incorporating tumor location into assessments can help select patients for de-escalated axillary surgery.
