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Neutrophil-to-HDL-C ratio and systemic inflammation response index are associated with the risk of abdominal aortic
Junqi Peng1, Dengwei Cao1, Yun Wu1
1Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Hubei Provincial Engineering Research Center of Minimally Invasive Cardiovascular Surgery, Wuhan 430071, China.; Wuhan Clinical Research Center for Minimally Invasive Treatment of Structural Heart Disease, Wuhan 430071, China.
Abstract:
Abdominal aortic aneurysm (AAA) is characterized by an inflammatory response that plays a crucial role in its pathogenesis. This study aimed to investigate the association between novel circulating inflammatory biomarkers and AAA. A total of 579 patients (240 with AAA and 339 with valvular heart disease as non-AAA controls) were enrolled from the Department of Cardiovascular Surgery at Zhongnan Hospital of Wuhan University between January 2020 and October 2024. Clinical characteristics and levels of circulating inflammatory markers were compared between the two groups. Multivariate logistic regression analyses indicated that male gender, lower HDLC, and higher neutrophil-to-HDL-C ratio (NHR), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) were independent but modest risk factors for AAA (P < 0.05). Furthermore, these biomarkers correlated with AAA severity. In conclusion, gender, HDLC, NHR, SIRI, and AISI serve as useful predictive factors for AAA. The nomogram prediction model demonstrated good discriminatory ability and may facilitate early diagnosis of AAA.
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