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Updated: Aug 6, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
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Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity

Daniel R Weilandt1, Won Dong Lee2, Michael R MacArthur1

  • 1Department of Chemistry, Princeton University, Princeton University, Princeton, NJ, USA; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton University, Princeton, NJ, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ, USA.

Cell Metabolism
|July 21, 2026
PubMed
Abstract

Keywords:
competitive catabolismdifferential equation modelinghyperinsulinemiainsulin regulationinsulin resistancemass action kineticsmetabolic homeostasisnutrient competitionobesitytype 2 diabetes

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