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LINC02207 suppresses breast cancer progression by promoting cuproptosis through NFAT5 regulation

JiCheng Chen1, Xinghang Fu1, Xiaotan Gao2

  • 1Department of Breast Surgery, Sanming First Hospital Affiliated to Fujian Medical University, Sanming, Fujian, 365500, China.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|July 21, 2026
PubMed
Abstract

Insights

Long non-coding RNA LINC02207 suppresses triple-negative breast cancer (TNBC) by promoting cuproptosis, a copper-mediated cell death. This discovery offers a potential new therapeutic target for TNBC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive subtype with limited targeted therapies.
  • Copper-mediated cell death (cuproptosis) is a promising therapeutic strategy.
  • Regulation of cuproptosis by non-coding RNAs in TNBC is underexplored.

Purpose of the Study:

  • Identify long non-coding RNAs (lncRNAs) involved in cuproptosis in TNBC.
  • Investigate the therapeutic potential of identified lncRNAs.

Main Methods:

  • Bioinformatic analysis of TCGA transcriptomic data.
  • Molecular, cellular, and in vivo model investigations.
  • Gene expression and protein interaction studies.

Main Results:

  • LINC02207 is downregulated in TNBC and associated with poor survival.
  • LINC02207 suppresses proliferation, promotes cuproptosis, and enhances sensitivity to Elesclomol.
  • LINC02207 interacts with NFAT5, regulating its nuclear localization and influencing cuproptosis.

Conclusions:

  • LINC02207 exhibits a tumor-suppressive role in TNBC via NFAT5-dependent cuproptosis regulation.
  • LINC02207 represents a potential therapeutic target for breast cancer treatment.
Keywords:
Breast cancerCuproptosisLINC02207NFAT5

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