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Updated: Aug 6, 2026
Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
Short Bowel Syndrome with Intestinal Failure: Healthcare Resource Utilization and Cost of Care in a Large US Claims
Ahan Ali1, Dejan Micic2, Mark Gallivan1
1Trinity Life Sciences, Waltham, MA, USA.
Objectives:
This retrospective, real-world analysis aimed to evaluate healthcare resource utilization (HCRU) and associated costs for patients with short bowel syndrome with intestinal failure (SBS-IF), who are dependent on parenteral support (PS), to provide insights into the disease burden.
Methods:
A rules-based algorithm identified and characterized patients with SBS-IF from 2019 to 2023 using Komodo Healthcare Map™ administrative claims data. HCRU and cost data were analyzed across the full cohort and sub-cohorts of age (3-17, 18-44, ≥45 years), nutrition claims/week (<0.5, 0.5-0.99, ≥1), and time since SBS surgery (<6 months versus >12 months since PS start).
Results:
Among 1587 patients with SBS-IF (mean follow-up 2.75 years), comorbidities included esophageal disorders, anxiety/depression, and liver and kidney disorders. SBS-IF management carried mean annualized costs of $166 483 for the full cohort, and up to $200 000 in the sub-cohort with ≥1 nutritional claim/week. Inpatient costs were highest, followed by home care costs. Overall mean annualized home care costs were $29 819. Patients with ≥1 nutrition claim/week had the highest nutrition costs ($68 235), driven by parenteral nutrition costs ($55 349). Bloodstream infections (BSIs) occurred in 47% of patients. Patients with BSIs had higher mean annualized costs of $241 868 and a longer median length of stay versus the full cohort (14 vs 8.1 days).
Conclusions:
SBS-IF represents a considerable burden, particularly in younger patients and those with greater nutritional needs, with high healthcare resource use, and substantial associated costs.
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